Antibody response to simian virus 40 tumor antigen in nude mice reconstituted with T cells
- PMID: 197168
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Antibody response to simian virus 40 tumor antigen in nude mice reconstituted with T cells
J Immunol.
1977 Sep.
Abstract
Athymic BALB/c nude mice (nu/nu) fail to generate circulating antibodies to simian virus 40 (SV40) tumor (T) antigen when immunized with SV40-transformed mouse cells or with T antigen positive somatic cell hybrids derived from SV40-transformed human and normal mouse parental cells. However, normal BALB/c mice readily produce antibodies to SV40 T antigen. When nude mice were reconstituted with normal syngeneic T lymphocytes from spleen or thymus source, the humoral immune responsiveness to SV40 T antigen was restored.
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