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. 2009 Sep;198(3):354-8.
doi: 10.1016/j.amjsurg.2008.09.027.

The necessity of chemotherapy in T3N0M0 colon cancer without risk factors

Hae Ran Yun  1 , Hee Cheol Kim, Woo Yong Lee, Yong Beom Cho, Seong Hyeon Yun, Ho-Kyung Chun
Affiliations

The necessity of chemotherapy in T3N0M0 colon cancer without risk factors

Hae Ran Yun et al. Am J Surg. 2009 Sep.

Abstract

Background: For patients with T3N0M0 colon cancer without known risk factors, the necessity of chemotherapy has no definite consensus.

Methods: From 1994 to 2004, we retrospectively analyzed 247 patients who had pathologically confirmed T3N0M0 colon cancer without risk factors.

Results: Among the 247 patients, 198 (80.2%) received chemotherapy and 49 (19.8%) underwent surgery alone. The 5-year survival rate was 92.8% for patients with T3N0M0 colon cancer without risk factors. Only chemotherapy increased survival (P = .032) by multivariate analysis. The 5-year survival rates were 85.4% in the surgery-only group and 94.2% in the group that received surgery with chemotherapy. There was no difference in the therapeutic efficacy of 5-fluorouracil, capecitabine, and uracil/tegafur (P = .424) for survival.

Conclusion: The results of this study showed that chemotherapy improved the survival of patients with T3N0M0 colon cancer without risk factors.

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