doi: 10.1093/infdis/136.supplement.s234.
Lymphocytosis-promoting factor of Bordetella pertussis: isolation, characterization, and biological activity
- PMID: 197175
- DOI: 10.1093/infdis/136.supplement.s234
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Lymphocytosis-promoting factor of Bordetella pertussis: isolation, characterization, and biological activity
J Infect Dis.
1977 Aug.
Abstract
The leukocytosis and lymphocytosis-promoting factor (LPF) of Bordetella pertussis has been isolated in apparently pure form. LPF is a protein essentially free of lipid and carbohydrate with an estimated molecular weight of 67,000-73,600 daltons. Purified LPF induced both histamine sensitization and refractoriness to epinephrine-induced hyperglycemia and was a murine thymus-derived (T-) cell mitogen. Adenyl cyclase activity also appeared to be associated with LPF.
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