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. 2009 Oct 15;25(20):2745-6.
doi: 10.1093/bioinformatics/btp518. Epub 2009 Aug 28.

ANCHOR: web server for predicting protein binding regions in disordered proteins

Zsuzsanna Dosztányi  1 , Bálint Mészáros, István Simon
Affiliations

ANCHOR: web server for predicting protein binding regions in disordered proteins

Zsuzsanna Dosztányi et al. Bioinformatics. .

Abstract

ANCHOR is a web-based implementation of an original method that takes a single amino acid sequence as an input and predicts protein binding regions that are disordered in isolation but can undergo disorder-to-order transition upon binding. The server incorporates the result of a general disorder prediction method, IUPred and can carry out simple motif searches as well.

Availability: The web server is available at http://anchor.enzim.hu. The program package is freely available for academic users.

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Figures

Fig. 1.
Fig. 1.
An example of ANCHOR graphical output for the Wiskott–Aldrich Syndrome protein (WASp) with various motif searches. The N-terminal of the protein contains an ordered domain, otherwise it is largely disordered. Multiple disordered binding regions were predicted, and several of these can be confirmed experimentally [see Mészáros et al. (2009) for more details]. The results of the motif searches show regions containing various SH3 binding sites as specified in the ELM database. Additionally, proline rich regions and the CRIB motif implicated in binding to Cdc42 can also be located.
See this image and copyright information in PMC

References

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