Marginal kidney donor
- PMID: 19718332
- PMCID: PMC2721608
- DOI: 10.4103/0970-1591.33726
Marginal kidney donor
Abstract
Renal transplantation is the treatment of choice for a medically eligible patient with end stage renal disease. The number of renal transplants has increased rapidly over the last two decades. However, the demand for organs has increased even more. This disparity between the availability of organs and waitlisted patients for transplants has forced many transplant centers across the world to use marginal kidneys and donors. We performed a Medline search to establish the current status of marginal kidney donors in the world. Transplant programs using marginal deceased renal grafts is well established. The focus is now on efforts to improve their results. Utilization of non-heart-beating donors is still in a plateau phase and comprises a minor percentage of deceased donations. The main concern is primary non-function of the renal graft apart from legal and ethical issues. Transplants with living donors outnumbered cadaveric transplants at many centers in the last decade. There has been an increased use of marginal living kidney donors with some acceptable medical risks. Our primary concern is the safety of the living donor. There is not enough scientific data available to quantify the risks involved for such donation. The definition of marginal living donor is still not clear and there are no uniform recommendations. The decision must be tailored to each donor who in turn should be actively involved at all levels of the decision-making process. In the current circumstances, our responsibility is very crucial in making decisions for either accepting or rejecting a marginal living donor.
Keywords: Complex living donor; deceased marginal donor; marginal kidney donor; non-heart-beating donor.
Conflict of interest statement
References
-
- Satayathum S, Pisoni RL, McCullough KP, Merion RM, Wikström B, Levin N, et al. Kidney transplantation and wait-listing rates from the international Dialysis Outcomes and Practice Patterns Study (DOPPS) Kidney Int. 2005;68:330–7. - PubMed
-
- Kumar A, Mandhani A, Verma BS, Srivastava A, Gupta A, Sharma RK, et al. Expanding the living related donor pool in renal transplantation: Use of marginal donors. J Urol. 2000;163:33–6. - PubMed
-
- Baid-Agrawal S, Frei UA. Living donor renal transplantation: Recent developments and perspectives. Nat Clin Pract Nephrol. 2007;3:31–41. - PubMed
-
- Cecka JM. The UNOS scientific renal transplant registry. In: Cecka JM, Terasaki PI, editors. Clinical transplants 1996. Los Angeles: UCLA Tissue Typing Laboratory; 1997. pp. 1–14.
-
- United Network for Organ Sharing Web site. Organ procurement and transplantation network data. Available from: http://www.unos.org. [Last accessed on 2005 Aug 15]
