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. 2009 Aug 6;11(15):3510-3.
doi: 10.1021/ol901366q.

Iridium-catalyzed coupling reaction of primary alcohols with 1-aryl-1-propynes leading to secondary homoallylic alcohols

Yasushi Obora  1 , Shintaro Hatanaka, Yasutaka Ishii
Affiliations

Iridium-catalyzed coupling reaction of primary alcohols with 1-aryl-1-propynes leading to secondary homoallylic alcohols

Yasushi Obora et al. Org Lett. .

Abstract

We report iridium-catalyzed coupling of 2-alkynes such as 1-aryl-1-propynes with primary alcohols leading to secondary homoallylic alcohols as products. This reaction involves an iridium-catalyzed novel catalytic transformation of 2-alkynes and primary alcohols through the formation of hydrido(pi-allyl)iridium as a possible key intermediate.

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