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. 1990;10(1):41-52.
doi: 10.1002/tcm.1770100106.

Rapid evaluation of topoisomerase inhibitors: caffeine inhibition of topoisomerases in vivo

C G Shin  1 , J M Strayer, M A Wani, R M Snapka
Affiliations

Rapid evaluation of topoisomerase inhibitors: caffeine inhibition of topoisomerases in vivo

C G Shin et al. Teratog Carcinog Mutagen. 1990.

Abstract

Caffeine was found to inhibit both type I and type II topoisomerases in vivo as judged by its effects on replicating simian virus 40 (SV40) chromosomes. The study was facilitated by the use of a rapid filter assay for the detection and characterization of topoisomerase inhibitors. The assay, which requires neither purified enzymes nor substrates, was able to identify both antagonists and poisons of type I and type II topoisomerases.

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