Electrophysiological effects of Chinese medicine Shen song Yang xin (SSYX) on Chinese miniature swine heart and isolated guinea pig ventricular myocytes
- PMID: 19719944
Electrophysiological effects of Chinese medicine Shen song Yang xin (SSYX) on Chinese miniature swine heart and isolated guinea pig ventricular myocytes
Abstract
Background: Shen song Yang xin (SSYX) is a compound of Chinese medicine with the effect of increasing heart rate (HR). This study aimed to evaluate its electrophysiological properties at heart and cellular levels.
Methods: The Chinese miniature swines were randomly assigned to two groups, administered with SSYX or placebo for 4 weeks (n = 8 per group). Cardiac electrophysiological study (EPS) was performed before and after drug administration. The guinea pig ventricular myocytes were enzymatically isolated and whole cell voltage-clamp technique was used to evaluate the effect of SSYX on cardiac action potential (AP).
Results: SSYX treatment accelerated the HR from (141.8 +/- 36.0) beats per minute to (163.0 +/- 38.0) beats per minute (P = 0.013) without changing the other parameters in surface electrocardiogram. After blockage of the autonomic nervous system with metoprolol and atropin, SSYX had no effect on intrinsic HR (IHR), but decreased corrected sinus node recovery time (CSNRT) and sinus atrium conducting time (SACT). Intra cardiac EPS showed that SSYX significantly decreased the A-H and A-V intervals as well as shortened the atrial (A), atrioventricular node (AVN) and ventricular (V) effective refractory period (ERP). In isolated guinea pig ventricular myocytes, the most obvious effect of SSYX on action potential was a shortening of the action potential duration (APD) without change in shape of action potential. The shortening rates of APD(30), APD(50) and APD(90) were 19.5%, 17.8% and 15.3%, respectively. The resting potential (Em) and the interval between the end of APD(30) and APD(90) did not significantly change.
Conclusions: The present study demonstrates that SSYX increases the HR and enhances the conducting capacity of the heart in the condition of the intact autonomic nervous system. SSYX homogenously decreases the ERP of the heart and shortens the APD of the myocytes, suggesting its antiarrhythmic effect without proarrhythmia.
Similar articles
-
Effects of Chinese herbs on multiple ion channels in isolated ventricular myocytes.Chin Med J (Engl). 2007 Jun 20;120(12):1068-74. Chin Med J (Engl). 2007. PMID: 17637224
-
Sphingosine-1-phosphate effects on guinea pig atrial myocytes: Alterations in action potentials and K+ currents.Cardiovasc Res. 2006 Apr 1;70(1):88-96. doi: 10.1016/j.cardiores.2006.01.010. Epub 2006 Mar 20. Cardiovasc Res. 2006. PMID: 16545787
-
The effects of paeonol on the electrophysiological properties of cardiac ventricular myocytes.Eur J Pharmacol. 2006 Sep 18;545(2-3):87-92. doi: 10.1016/j.ejphar.2006.06.064. Epub 2006 Jul 1. Eur J Pharmacol. 2006. PMID: 16876781
-
A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system.Prog Biophys Mol Biol. 2008 Jan-Apr;96(1-3):258-80. doi: 10.1016/j.pbiomolbio.2007.07.022. Epub 2007 Aug 11. Prog Biophys Mol Biol. 2008. PMID: 17888503 Review.
-
Shen Song Yang Xin Capsule Combined with Antiarrhythmic Drugs, a New Integrative Medicine Therapy, for the Treatment of Frequent Premature Ventricular Contractions (FPVC): A Meta-Analysis of Randomized Controlled Trials.Evid Based Complement Alternat Med. 2014;2014:976713. doi: 10.1155/2014/976713. Epub 2014 Mar 18. Evid Based Complement Alternat Med. 2014. PMID: 24772186 Free PMC article. Review.
Cited by
-
The Different Therapeutic Effects of Traditional Chinese Medicine Shensong Yangxin Capsule and Salubrinal in High-intensity Exercise-induced Heart Failure in Rats with Acute Myocardial Infarction.Comb Chem High Throughput Screen. 2024;27(11):1592-1601. doi: 10.2174/0113862073272407231201071629. Comb Chem High Throughput Screen. 2024. PMID: 38305401
-
Atrial tachyarrhythmia prevention by Shensong Yangxin after catheter ablation for persistent atrial fibrillation: the SS-AFRF trial.Eur Heart J. 2024 Oct 21;45(40):4305-4314. doi: 10.1093/eurheartj/ehae532. Eur Heart J. 2024. PMID: 39178138 Free PMC article. Clinical Trial.
-
Effect of Shensong Yangxin on the Progression of Paroxysmal Atrial Fibrillation is Correlated with Regulation of Autonomic Nerve Activity.Chin Med J (Engl). 2017 Jan 20;130(2):171-178. doi: 10.4103/0366-6999.197997. Chin Med J (Engl). 2017. PMID: 28091409 Free PMC article.
-
Clinical Efficacy and Safety of Shensong Yangxin Capsule-Amiodarone Combination on Heart Failure Complicated by Ventricular Arrhythmia: A Meta-Analysis of Randomized Controlled Trials.Front Pharmacol. 2021 Feb 22;12:613922. doi: 10.3389/fphar.2021.613922. eCollection 2021. Front Pharmacol. 2021. PMID: 33692689 Free PMC article. Review.
-
Shensong yangxin, a multi-functional traditional Chinese medicine for arrhythmia: A review of components, pharmacological mechanisms, and clinical applications.Heliyon. 2024 Aug 2;10(16):e35560. doi: 10.1016/j.heliyon.2024.e35560. eCollection 2024 Aug 30. Heliyon. 2024. PMID: 39224243 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources