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Review
. 2009 Sep;8(9):724-32.
doi: 10.1038/nrd2974.

Protein methyltransferases as a target class for drug discovery

Robert A Copeland  1 , Michael E Solomon, Victoria M Richon
Affiliations
Review

Protein methyltransferases as a target class for drug discovery

Robert A Copeland et al. Nat Rev Drug Discov. 2009 Sep.

Abstract

The protein methyltransferases (PMTs) - which methylate protein lysine and arginine residues and have crucial roles in gene transcription - are emerging as an important group of enzymes that play key parts in normal physiology and human diseases. The collection of human PMTs is a large and diverse group of enzymes that have a common mechanism of catalysis. Here, we review the biological, biochemical and structural data that together present PMTs as a novel, chemically tractable target class for drug discovery.

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References

    1. Cell. 1992 Nov 13;71(4):691-700 - PubMed
    1. PLoS One. 2008 Apr 30;3(4):e2037 - PubMed
    1. J Biol Chem. 2008 Sep 26;283(39):26771-81 - PubMed
    1. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5728-32 - PubMed
    1. Annu Rev Biophys Biomol Struct. 2005;34:267-94 - PubMed

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