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Case Reports
. 2009:2009:378287.
doi: 10.1155/2009/378287. Epub 2009 Aug 9.

Myopathy with concurrent tadalafil and simvastatin

Maria Pia Gargante  1 , Marco Vacante, Cristina Russo, Mariano Malaguarnera
Affiliations
Case Reports

Myopathy with concurrent tadalafil and simvastatin

Maria Pia Gargante et al. Case Rep Med. 2009.

Abstract

A 48-year-old man, using statin, was admitted to hospital with progressive myalgia after consumption of tadalafil and simvastatin. Muscle pain and penile erection disappeared seven days after interruption of therapy. This case demonstrates the interaction of tadalafil with simvastatin resulting in myopathy. Muscle damage could be attributed to the common metabolic way of these two drugs which is cytochrome P450 isoenzyme system.

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