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Case Reports
. 2009:2009:378287.
doi: 10.1155/2009/378287. Epub 2009 Aug 9.

Myopathy with concurrent tadalafil and simvastatin

Maria Pia Gargante  1 , Marco Vacante, Cristina Russo, Mariano Malaguarnera
Affiliations
Case Reports

Myopathy with concurrent tadalafil and simvastatin

Maria Pia Gargante et al. Case Rep Med. 2009.

Abstract

A 48-year-old man, using statin, was admitted to hospital with progressive myalgia after consumption of tadalafil and simvastatin. Muscle pain and penile erection disappeared seven days after interruption of therapy. This case demonstrates the interaction of tadalafil with simvastatin resulting in myopathy. Muscle damage could be attributed to the common metabolic way of these two drugs which is cytochrome P450 isoenzyme system.

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References

    1. Kendirci M, Nowfar S, Hellstrom WJ. The impact of vascular risk factors on erectile function. Drugs of Today. 2005;41(1):65–74. - PubMed
    1. Ring BJ, Patterson BE, Mitchell MI, et al. Effect of tadalafil on cytochrome P450 3A4-mediated clearance: studies in vitro and in vivo. Clinical Pharmacology and Therapeutics. 2005;77(1):63–75. - PubMed
    1. Prueksaritanont T, Ma B, Yu N. The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6. British Journal of Clinical Pharmacology. 2003;56(1):120–124. - PMC - PubMed
    1. Rosano GM, Aversa A, Vitale C, Fabbri A, Fini M, Spera G. Chronic treatment with Tadalafil improves endothelial function in men with increased cardiovascular risk. European Urology. 2005;47(2):214–222. - PubMed
    1. Solomon H, Wierzbicki AS, Lumb PJ, Lambert-Hammill M, Jackson G. Cardiovascular risk factors determine erectile and arterial function response to Sildenafil. American Journal of Hypertension. 2006;19(9):915–919. - PubMed

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