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Review
. 2009 Aug:1171:87-93.
doi: 10.1111/j.1749-6632.2009.04909.x.

eEF1A2 as a putative oncogene

Mee-Hyun Lee  1 , Young-Joon Surh
Affiliations
Review

eEF1A2 as a putative oncogene

Mee-Hyun Lee et al. Ann N Y Acad Sci. 2009 Aug.

Abstract

The first evidence for the role of the protein elongation factor eEF1A2 in tumorigenesis was reported by Anand and colleagues who demonstrated that eEF1A2 is overexpressed in about 30% of ovarian tumors and some established ovarian cancer cells. This abnormal expression correlates with a poor prognosis. Since this discovery, there have been several reports suggesting eEF1A2 as a diagnostic marker in various cancers. This review highlights the oncogenic potential of eEF1A2.

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