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Comment
. 2009 Sep;10(3):162-4.
doi: 10.1016/j.cmet.2009.08.005.

Bile acids have the gall to function as hormones

Thomas Quad de Aguiar Vallim  1 , Peter A Edwards
Affiliations
Free article
Comment

Bile acids have the gall to function as hormones

Thomas Quad de Aguiar Vallim et al. Cell Metab. 2009 Sep.
Free article

Abstract

In this issue of Cell Metabolism, Thomas et al. (2009) show that specific activation of the bile-acid-activated G protein-coupled receptor TGR5 improves pancreatic and hepatic function and impairs the development of obesity following administration of a high-fat diet.

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  • TGR5-mediated bile acid sensing controls glucose homeostasis.
    Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J, Schoonjans K. Thomas C, et al. Cell Metab. 2009 Sep;10(3):167-77. doi: 10.1016/j.cmet.2009.08.001. Cell Metab. 2009. PMID: 19723493 Free PMC article.

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