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. 2009;48(40):7346-9.
doi: 10.1002/anie.200903556.

Imparting multivalency to a bifunctional chelator: a scaffold design for targeted PET imaging probes

Wei Liu  1 , Guiyang Hao, Michael A Long, Tiffani Anthony, Jer-Tsong Hsieh, Xiankai Sun
Affiliations

Imparting multivalency to a bifunctional chelator: a scaffold design for targeted PET imaging probes

Wei Liu et al. Angew Chem Int Ed Engl. 2009.
No abstract available

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Figures

Figure 1
Figure 1
Chemical structures of relevant compounds
Figure 2
Figure 2
Representative microPET-CT images of PC-3 tumor bearing mice (n = 3) at 1, 4, 24 h after intravenous injection of 64Cu-1 (upper panel) and 64Cu-2 (lower panel). Images obtained with coinjection of 10 mg/kg of c(RGDyK) were only shown for 1 h blockade (right). Solid arrows indicate tumors.
Scheme 1
Scheme 1
Synthesis of H21 and H22. Reagents: (i-1 and i-2) CH2Cl2, K2CO3; (ii) BrCH2COOtBu, CH2Cl2, K2CO3; (iii) and (vii) 10% Pd/C, THF/H2O; (iv) and (viii) MeCN, NHS, EDC; (vi) and (ix) c(RGDyK), DIPEA, DMF; (v) and (x) 95% TFA.
See this image and copyright information in PMC

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