Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1990 May;10(4):544-7.
doi: 10.1097/00005176-199005000-00020.

Nonocclusive mesenteric ischemia associated with propranolol overdose: implications regarding splanchnic circulation

M J Pettei  1 , J Levy, S Abramson
Affiliations
Case Reports

Nonocclusive mesenteric ischemia associated with propranolol overdose: implications regarding splanchnic circulation

M J Pettei et al. J Pediatr Gastroenterol Nutr. 1990 May.

Abstract

We describe a case of massive propranolol overdose in a healthy 19-year-old woman associated with isolated mesenteric ischemia following shock. We postulate that endogenous catecholamine release from shock combined with massive beta-adrenergic blockade led to severe splanchnic vasoconstriction from unopposed alpha-adrenergic activity. This case supports current thinking regarding the effect of vasoactive mediators on the gastrointestinal tract in humans and might be relevant to the mechanism of action of propranolol in the prophylaxis of variceal bleeding.

PubMed Disclaimer

Publication types

LinkOut - more resources