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Review
. 2009;11(5):503-15.
doi: 10.1080/14653240903193806.

Mesenchymal stem cells in hematopoietic stem cell transplantation

Minoo Battiwalla  1 , Peiman Hematti
Affiliations
Review

Mesenchymal stem cells in hematopoietic stem cell transplantation

Minoo Battiwalla et al. Cytotherapy. 2009.

Abstract

Mesenchymal stromal/stem cells (MSC) of bone marrow (BM) origin not only provide the supportive microenvironmental niche for hematopoietic stem cells (HSC) but are capable of differentiating into various cell types of mesenchymal origin, such as bone, fat and cartilage. In vitro and in vivo data suggest that MSC have low inherent immunogenicity, modulate/suppress immunologic responses through interactions with immune cells, and home to damaged tissues to participate in regeneration processes through their diverse biologic properties. MSC derived from BM are being evaluated for a wide range of clinical applications, including disorders as diverse as myocardial infarction and newly diagnosed diabetes mellitus type 1. However, their use in HSC transplantation, either for enhancement of hematopoietic engraftment or for treatment/prevention of graft-versus-host disease, is far ahead of other indications. Ease of isolation and ex vivo expansion of MSC, combined with their intriguing immunomodulatory properties and their impressive record of safety in a wide variety of clinical trials, make these cells promising candidates for further investigation.

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Figures

Figure 1
Figure 1
Mechanisms of action and potential role of mesenchymal stem cells in hematopoietic stem cell transplantation.
See this image and copyright information in PMC

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