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Review
. 2009 Oct;9(10):729-40.
doi: 10.1038/nri2620. Epub 2009 Sep 4.

Complement regulators and inhibitory proteins

Peter F Zipfel  1 , Christine Skerka
Affiliations
Review

Complement regulators and inhibitory proteins

Peter F Zipfel et al. Nat Rev Immunol. 2009 Oct.

Abstract

The complement system is important for cellular integrity and tissue homeostasis. Complement activation mediates the removal of microorganisms and the clearance of modified self cells, such as apoptotic cells. Complement regulators control the spontaneously activated complement cascade and any disturbances in this delicate balance can result in damage to tissues and in autoimmune disease. Therefore, insights into the mechanisms of complement regulation are crucial for understanding disease pathology and for enabling the development of diagnostic tools and therapies for complement-associated diseases.

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References

    1. Mol Immunol. 2008 Oct;45(16):4057-63 - PubMed
    1. Arthritis Rheum. 2007 Apr;56(4):1187-97 - PubMed
    1. Immunol Rev. 2008 Jun;223:300-16 - PubMed
    1. Nat Genet. 2006 Apr;38(4):458-62 - PubMed
    1. Nature. 2009 Apr 16;458(7240):890-3 - PubMed

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