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. 1990 Jul;7(3):382-8.
doi: 10.1016/0888-7543(90)90172-q.

A physical map of the human PI and AACT genes

L Sefton  1 , G Kelsey, P Kearney, S Povey, J Wolfe
Affiliations

A physical map of the human PI and AACT genes

L Sefton et al. Genomics. 1990 Jul.

Abstract

We have used probes from the human genes PI, PIL, and AACT (alpha 1-antitrypsin, alpha 1-antitrypsin-related sequence, and alpha 1-antichymotrypsin) to make a pulsed-field map of the surrounding region of 14q31-32. We have discovered that the PI-PIL gene cluster is only 220 kb away from the AACT gene and that it is orientated in the opposite direction. The comparatively short distance between the genes comes as a surprise given previous estimates of the level of genetic recombination between them.

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