The yin-yang of tumor-associated neutrophils
- PMID: 19732714
- DOI: 10.1016/j.ccr.2009.08.014
The yin-yang of tumor-associated neutrophils
Abstract
Cancer-related inflammation is a key component of the tumor microenvironment. A report in this issue of Cancer Cell now indicates that tumor-associated neutrophils in lung cancer can polarize to either "N1" or "N2" phenotype that inhibits or promotes cancer development, respectively.
Comment on
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Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN.Cancer Cell. 2009 Sep 8;16(3):183-94. doi: 10.1016/j.ccr.2009.06.017. Cancer Cell. 2009. PMID: 19732719 Free PMC article.
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