Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Sep 8;16(3):174-6.
doi: 10.1016/j.ccr.2009.08.012.

Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way

Matthew P Strout  1 , David G Schatz
Affiliations
Free article
Comment

Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way

Matthew P Strout et al. Cancer Cell. .
Free article

Abstract

Very little is known about how acquired oncogenic mutations arise. In this issue of Cancer Cell, Klemm and colleagues present evidence supporting a role for the antibody diversification enzyme activation-induced deaminase (AID) in the generation of mutations associated with disease progression and drug resistance in chronic myeloid leukemia.

PubMed Disclaimer

Comment on

MeSH terms

LinkOut - more resources