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Comment
. 2009 Sep 8;16(3):178-80.
doi: 10.1016/j.ccr.2009.08.011.

A molecular link between AKT regulation and chemotherapeutic response

Christian C Dibble  1 , Brendan D Manning
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Free article
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A molecular link between AKT regulation and chemotherapeutic response

Christian C Dibble et al. Cancer Cell. .
Free article

Abstract

The protein kinase AKT is frequently activated in human cancers and has been implicated in resistance to chemotherapy. In this issue of Cancer Cell, Pei et al. show that FKBP51 negatively regulates AKT through the phosphatase PHLPP. This regulation appears to be a determinant of chemosensitivity in cancer cells.

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