Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Sep;17(9):399-405.
doi: 10.1016/j.tim.2009.06.003. Epub 2009 Sep 3.

On the facultative requirement of the bacterial RNA chaperone, Hfq

Ambre Jousselin  1 , Laurent Metzinger, Brice Felden
Affiliations
Free article

On the facultative requirement of the bacterial RNA chaperone, Hfq

Ambre Jousselin et al. Trends Microbiol. 2009 Sep.
Free article

Abstract

The pleiotropic post-transcriptional regulator Hfq is an RNA chaperone that facilitates pairing interactions between small regulatory RNAs (sRNAs) and their mRNA targets in several bacteria. However, this classical pattern, derived from the Escherichia coli model, is not applicable to the whole bacterial kingdom. In this article we discuss the facultative requirement for Hfq for sRNA-mRNA duplex formation among bacteria and the specific features of the Hfq protein and RNA duplexes that might account for the dispensability or requirement of the chaperone. Apparent links between the need for Hfq, the GC content of bacterial genomes and the free energy of experimentally validated sRNA-mRNA pairing interactions are presented.

PubMed Disclaimer

Publication types

LinkOut - more resources