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Controlled Clinical Trial
. 2009 Dec;8(6):392-9.
doi: 10.1016/j.jcf.2009.08.001. Epub 2009 Sep 4.

Non-invasive liver elastography (Fibroscan) for detection of cystic fibrosis-associated liver disease

Peter Witters  1 , Kris De Boeck, Lieven Dupont, Marijke Proesmans, François Vermeulen, Roger Servaes, Chris Verslype, Wim Laleman, Frederik Nevens, Ilse Hoffman, David Cassiman
Affiliations
Free article
Controlled Clinical Trial

Non-invasive liver elastography (Fibroscan) for detection of cystic fibrosis-associated liver disease

Peter Witters et al. J Cyst Fibros. 2009 Dec.
Free article

Abstract

Background: Cystic fibrosis-associated liver disease (CFLD) is the second cause of mortality in CF. The prevalence is estimated to be 26-45%, but sensitive diagnostic tools are lacking. We investigated whether non-invasive liver elastography (Fibroscan) could serve as a screening tool.

Methods: Fibroscan measurements were performed in 66 CF patients. Age-specific cutoff values were determined in a control population (n=59). The measurements were compared to clinical data, bi-yearly biochemistry and ultrasound.

Results: Fibroscan was easy to perform in this patient population. There were 14 patients (21%) with abnormal liver stiffness measurements. Liver stiffness was significantly increased in patients with clinical CFLD (11.2 kPa versus 5.1 kPa), biochemical CFLD (7.4 kPa versus 5.4 kPa) or ultrasonographical CFLD (8.2 versus 4.3 kPa) (p<0.02 for all).

Conclusions: Fibroscan is an objective measure and is easy to perform in CF patients, even in children and could provide a valuable tool to detect, and quantify CFLD.

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