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. 2009 Sep;201(3):269.e1-269.e10.
doi: 10.1016/j.ajog.2009.06.060.

Health of children born to mothers who had preeclampsia: a population-based cohort study

Chun S Wu  1 , Ellen A Nohr, Bodil H Bech, Mogens Vestergaard, Janet M Catov, Jørn Olsen
Affiliations

Health of children born to mothers who had preeclampsia: a population-based cohort study

Chun S Wu et al. Am J Obstet Gynecol. 2009 Sep.

Abstract

Objective: We assessed whether preeclampsia correlates with the long-term postnatal health of the offspring.

Study design: We conducted a population-based cohort study of 1,618,481 singletons born in Denmark (1978-2004) with up to 27 years of follow-up. We used Cox regression to estimate the associations between preeclampsia and long-term health outcomes of the offspring.

Results: Children born at term exposed to preeclampsia had an increased risk of a variety of diseases, such as endocrine, nutritional, and metabolic diseases (incidence rate ratio, 1.6; 95% confidence interval, 1.5-1.7), and diseases of the blood and blood-forming organs (incidence rate ratio, 1.5; 95% confidence interval, 1.3-1.8). Children born preterm exposed to preeclampsia had a similar pattern of hospitalizations compared with the children born preterm unexposed to preeclampsia, although they had a decreased risk of cerebral palsy (incidence rate ratio, 0.7; 95% confidence interval, 0.6-0.9).

Conclusion: Preeclampsia was associated with an increased risk of being hospitalized for a number of diseases, especially in the children born at term.

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