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. 2009 Sep;94(9):1326-9.
doi: 10.3324/haematol.2009.007823.

Elevated profile of Th17, Th1 and Tc1 cells in patients with immune thrombocytopenic purpura

Jingbo Zhang, Daoxin Ma, Xiaojuan Zhu, Xun Qu, Chunyan Ji, Ming Hou

Elevated profile of Th17, Th1 and Tc1 cells in patients with immune thrombocytopenic purpura

Jingbo Zhang et al. Haematologica. 2009 Sep.
No abstract available

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Figures

Figure 1.
Figure 1.
Circulating percentages of Th1, Tc1 and Th17 increased in ITP patients compared with controls. (A) CD3+ T subsets were gated by flow cytometry. Plots in intern box represented CD3+ T cells. (B) Representative IFN-γ and IL-17 expression in CD3+CD8−≠T subsets (CD4+ T subsets) and CD3+CD8+ T subsets from each group was shown. The percentage of positive cells was shown in each panel. (C) The percentage of circulating Th1 was significantly higher in ITP patients (15.50±4.20%), as compared with the control group (11.6±4.23%) (p<0.01). (D) The percentage of circulating Tc1 was significantly higher in ITP patients (19.96±8.91%) than that in the control group (13.71±6.77%) (p<0.05). (E) The percentage of circulating Th17 was markedly higher in ITP patients (1.94±0.93%) than that of normal controls (1.33±0.64%) (p<0.05).
Figure 2.
Figure 2.
Correlations of Th1/Tc1, Th17/Th1 and Th17/Tc1 in ITP patients. (A) Th1 percentage positively correlated with the percentage of Tc1 (r=0.58, p=0.01). (B) Th17 percentage positively correlated with the percentage of Th1 (r=0.61, p=0.007). (C) There was no significant correlation between Th17 and Tc1 (r=0.09, p=0.71).
See this image and copyright information in PMC

References

    1. Semple JW, Milev Y, Cosgrave D, Mody M, Hornstein A, Blanchette V, et al. Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity. Blood. 1996;87:4245–54. - PubMed
    1. Panitsas FP, Theodoropoulou M, Kouraklis A, Karakantza M, Theodorou GL, Zoumbos NC, et al. Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response. Blood. 2004;103:2645–7. - PubMed
    1. Wang T, Zhao H, Ren H, Guo J, Xu M, Yang R, et al. Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura. Haematologica. 2005;90:914–23. - PubMed
    1. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005;6:1133–41. - PMC - PubMed
    1. Shahrara S, Huang Q, Mandelin AM, 2nd, Pope RM. TH-17 cells in rheumatoid arthritis. Arthritis Res Ther. 2008;10:R93. - PMC - PubMed

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