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Comment
. 2009 Sep;15(9):993-4.
doi: 10.1038/nm0909-993.

Blocking the path of lymphatic vessels

Mihaela Skobe  1 , Reza Dana
Affiliations
Comment

Blocking the path of lymphatic vessels

Mihaela Skobe et al. Nat Med. 2009 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Function of lymphatic and blood vessels in adaptive immunity and corneal transplant rejection. Lymphatics transport antigens and antigen-presenting cells (APCs) from the graft site to the draining lymph nodes, where the T cell response is primed and expanded. Effector (alloreactive) T helper 1 cells return to the cornea and mediate transplant rejection by primarily generating a delayed hypersensitivity response. Blocking lymphangiogenesis or angiogenesis can promote graft longevity by suppressing egress of APCs to the lymph nodes and by preventing homing of T cells to the transplant, respectively. Albuquerque et al. identify a factor that inhibits lymphangiogenesis that has potential as a therapeutic target.
See this image and copyright information in PMC

Comment on

References

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