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Controlled Clinical Trial
. 2009 Oct;29(10):1042-8.
doi: 10.1111/j.1468-2982.2008.01834.x. Epub 2009 Mar 12.

Ictal and interictal phonophobia in migraine-a quantitative controlled study

A Ashkenazi  1 , A Mushtaq, I Yang, M L Oshinsky
Affiliations
Controlled Clinical Trial

Ictal and interictal phonophobia in migraine-a quantitative controlled study

A Ashkenazi et al. Cephalalgia. 2009 Oct.

Abstract

The aim of the study was to evaluate quantitatively ictal and interictal phonophobia in episodic migraine (EM). We included subjects with EM and age- and gender-matched controls. Sound stimuli were pure tones at frequencies of 1000, 4000 and 8000 Hz. Sound aversion thresholds (SATs) were determined as the minimal sound intensity perceived as unpleasant or painful. Migraineurs were examined both between and during attacks. We compared interictal SATs in migraineurs with those in controls. We also compared ictal and interictal SATs in migraineurs. Sixty migraineurs and 52 controls were included. Interictal mean SAT of migraineurs, averaged for the three frequencies, was significantly lower than that of controls [90.4 (0.8) dB vs. 105.9 (1.1) dB, respectively, P < 0.0001]. In migraineurs, mean ictal SAT, averaged for the three frequencies, was significantly lower than interictal SAT [76.0 (0.9) dB vs. 91.0 (0.8) dB, respectively, P < 0.0001]. Patients with EM exhibit increased sound aversion between attacks that is further augmented during an acute attack.

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Figures

Figure 1
Figure 1
A graph showing the results of sound aversion testing in a migraine patient during an attack.
Figure 2
Figure 2
Mean interictal sound aversion thresholds (SATs) in the migraine group vs. SATs in the control group.
Figure 3
Figure 3
Mean interictal and ictal sound aversion thresholds in the migraine group.
See this image and copyright information in PMC

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