Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jun;80(3):400-3.
doi: 10.1111/j.1365-2249.1990.tb03300.x.

HLA-DR, DQ and T cell antigen receptor constant beta genes in Japanese patients with ulcerative colitis

K Kobayashi  1 , M Atoh, Y Konoeda, A Yagita, H Inoko, S Sekiguchi
Affiliations

HLA-DR, DQ and T cell antigen receptor constant beta genes in Japanese patients with ulcerative colitis

K Kobayashi et al. Clin Exp Immunol. 1990 Jun.

Abstract

We studied the T cell antigen receptor (TcR) constant beta chain genes on HLA typed Japanese patients with ulcerative colitis (UC). A TcR constant beta EcoRI 6.0-kb fragment was present in all Japanese UC patients (n = 17) but completely absent in the controls (n = 35) (chi2 = 47.6, P less than 0.001). The frequency of HLA-DR2 antigen was significantly higher in UC patients (85% versus 28% in controls, P less than 0.001). Furthermore, HLA-DQw1 antigen was also increased in UC patients (96% versus 60% in controls, P less than 0.001). However, HLA-DR4 antigen was significantly decreased in UC patients (12% versus 37%, P = 0.02). HLA-DR1 antigen was not found in UC patients and was present in only 15% of the controls. These results suggest that TcR beta chain and HLA-DQw1 antigen may be important in the pathogenesis of Japanese UC.

PubMed Disclaimer

References

    1. J Exp Med. 1975 Jun 1;141(6):1427-36 - PubMed
    1. Clin Exp Immunol. 1987 Oct;70(1):152-7 - PubMed
    1. Gastroenterology. 1982 Mar;82(3):413-8 - PubMed
    1. N Engl J Med. 1982 Apr 8;306(14):837-48 - PubMed
    1. Anal Biochem. 1983 Jul 1;132(1):6-13 - PubMed

Publication types