Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Sep 4;138(5):822-9.
doi: 10.1016/j.cell.2009.08.017.

Heterogeneity in cancer: cancer stem cells versus clonal evolution

Mark Shackleton  1 , Elsa Quintana, Eric R Fearon, Sean J Morrison
Affiliations
Free article

Heterogeneity in cancer: cancer stem cells versus clonal evolution

Mark Shackleton et al. Cell. .
Free article

Abstract

The identification and characterization of cancer stem cells might lead to more effective treatments for some cancers by focusing therapy on the most malignant cells. To achieve this goal it will be necessary to determine which cancers follow a cancer stem cell model and which do not, to address technical issues related to tumorigenesis assays, and to test the extent to which cancer cell heterogeneity arises from genetic versus epigenetic differences.

PubMed Disclaimer

Publication types

LinkOut - more resources