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. 2009 Sep 15;15(18):5606-8.
doi: 10.1158/1078-0432.CCR-09-1575. Epub 2009 Sep 8.

Prevention of progression in monoclonal gammopathy of undetermined significance

S Vincent Rajkumar  1
Affiliations

Prevention of progression in monoclonal gammopathy of undetermined significance

S Vincent Rajkumar. Clin Cancer Res. .

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) is a common premalignant plasma cell proliferative disorder with a lifelong risk of progression to multiple myeloma. Because myeloma is an incurable malignancy, strategies to delay or prevent progression in high-risk patients are of considerable importance.

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Figures

Figure 1
Figure 1. Pathogenesis of MGUS and its Progression to Myeloma
The initiation of limited clonal plasma cell proliferation in MGUS is likely triggered by an abnormal response to antigenic stimulation in a genetically or environmentally susceptible host, and development of typical cytogenetic abnormalities, hyperdiploidy or IgH translocations. Progression of MGUS to myeloma is accompanied by a variety of changes in the clonal cell and its microenvironment. MGUS, monoclonal gammopathy of undetermined significance; IgH, immunoglobulin heavy chain.
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References

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