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. 2009 Dec;8(6):418-24.
doi: 10.1016/j.jcf.2009.08.002. Epub 2009 Sep 8.

A safe protocol for rapid desensitization in patients with cystic fibrosis and antibiotic hypersensitivity

Henry J Legere 3rd  1 , Ross I Palis, Tito Rodriguez Bouza, Ahmet Z Uluer, Mariana C Castells
Affiliations

A safe protocol for rapid desensitization in patients with cystic fibrosis and antibiotic hypersensitivity

Henry J Legere 3rd et al. J Cyst Fibros. 2009 Dec.

Abstract

Background: CF patients often demonstrate hypersensitivity to one or multiple antibiotics due to frequent and repeated exposures. Attempts at antibiotic desensitization in this population are historically complicated by higher reaction rates, failure to complete the procedure and consequent withholding of first-line therapy. This study evaluates the outcomes of a rapid desensitization protocol developed at our institution.

Methods: We retrospectively reviewed the medical records of 15 patients undergoing 52 rapid antibiotic desensitizations at Brigham and Women's Hospital and Children's Hospital Boston utilizing our protocol.

Results: Mean FEV1 % predicted was 44.1 (SD 16.5), with two patients at <30% and one patient desensitized during bilateral lung transplantation. Adverse reactions during desensitization occurred in 13.4%, and most were mild. 100% of patients completed the protocol and ultimately tolerated subsequent full-strength antibiotic courses.

Conclusions: CF patients with antibiotic hypersensitivity can safely receive first-line antibiotics via our rapid desensitization protocol, including those with severe obstructive lung disease.

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Figures

Figure 1
Figure 1
Examples of desensitization protocols using various target antibiotic concentrations
Figure 1
Figure 1
Examples of desensitization protocols using various target antibiotic concentrations
Figure 1
Figure 1
Examples of desensitization protocols using various target antibiotic concentrations
Figure 2
Figure 2
Pearls from our experience
See this image and copyright information in PMC

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