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. 2009 Sep 10;361(11):1114-6.
doi: 10.1056/NEJMcibr0905244.

Understanding abdominal aortic aneurysm

Neal L Weintraub  1
Affiliations

Understanding abdominal aortic aneurysm

Neal L Weintraub. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. A Model of Cyclophilin A and Abdominal Aortic Aneurysms
A recent study by Satoh et al. showed that angiotensin II, through induction of reactive oxygen species, induces cyclophilin A in smooth-muscle cells; this, in turn, triggers recruitment of inflammatory cells, activation of matrix metalloproteinase-2, and production of reactive oxygen species. Together, these factors lead to matrix degradation, apoptosis of smooth-muscle cells, and consequently, aneurysm formation. Cyclophilin A, itself induced by reactive oxygen species, acts through autocrine and paracrine mechanisms to up-regulate production of reactive oxygen species; this is indicative of a positive feedback loop.
See this image and copyright information in PMC

References

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