Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Dec;22(6):553-8.
doi: 10.1097/QCO.0b013e3283321ccc.

Pediatric antifungal agents

Michael Cohen-Wolkowiez  1 , Cassandra Moran, Daniel K Benjamin Jr, Phillip B Smith
Affiliations
Review

Pediatric antifungal agents

Michael Cohen-Wolkowiez et al. Curr Opin Infect Dis. 2009 Dec.

Abstract

Purpose of review: In immunocompromised hosts, invasive fungal infections are common and fatal. In the past decade, the antifungal armamentarium against invasive mycoses has expanded greatly. The purpose of the present report is to review the most recent literature addressing the use of antifungal agents in children.

Recent findings: Most studies evaluating the safety and efficacy of antifungal agents are limited to adults. However, important progress has been made in describing the pharmacokinetics and safety of newer antifungal agents in children, including the echinocandins.

Summary: Dosage guidelines for newer antifungal agents are currently based on adult and limited pediatric data. Because important developmental pharmacology changes occur throughout childhood impacting the pharmacokinetics of these agents, antifungal studies specifically designed for children are necessary.

PubMed Disclaimer

References

    1. Atkinson AJ, Jr, Bennett JE. Amphotericin B pharmacokinetics in humans. Antimicrobial Agents and Chemotherapy. 1978;13:271–6. - PMC - PubMed
    1. Baley JE, Meyers C, Kliegman RM, et al. Pharmacokinetics, outcome of treatment, and toxic effects of amphotericin B and 5-fluorocytosine in neonates. J Pediatr. 1990 May;116(5):791–7. - PubMed
    1. Luna B, Drew RH, Perfect JR. Agents for treatment of invasive fungal infections. Otolaryngologic Clinics of North America. 2000;33:277–99. - PubMed
    1. Gallis HA, Drew RH, Pickard WW. Amphotericin B: 30 years of clinical experience. Reviews of Infectious Diseases. 1990;12:308–29. - PubMed
    1. Dismukes WE. Introduction to antifungal agents. Clinical Infectious Diseases. 2000;30:653–7. - PubMed

Publication types