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Review
. 1990 Jul;15(7):277-81.
doi: 10.1016/0968-0004(90)90054-f.

How the messenger got its tail: addition of poly(A) in the nucleus

M Wickens  1
Affiliations
Review

How the messenger got its tail: addition of poly(A) in the nucleus

M Wickens. Trends Biochem Sci. 1990 Jul.

Abstract

Most mRNAs end in a poly(A) tail, the addition of which is catalysed by a poly(A) polymerase in conjunction with a distinct factor that provides specificity for mRNAs. The reaction is dynamic, involving separable initiation, elongation and termination phases. A companion article in next month's TIBS will review the regulation of poly(A) addition and removal during early animal development.

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