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. 1990 May;91(5):363-8.

[The effect of adrenergic beta receptor blockers on phospholipid metabolism in mast cells]

[Article in Slovak]
J Pecivová  1 , K Drábiková, R Nosál'
Affiliations
  • PMID: 1974476

[The effect of adrenergic beta receptor blockers on phospholipid metabolism in mast cells]

[Article in Slovak]
J Pecivová et al. Bratisl Lek Listy. 1990 May.

Abstract

The aim of this study was to determine whether beta adrenergic receptor blocking drugs exaprolol, metipranolol and propranolol effect the metabolism of phospholipids in isolated rat mast cells. The phospholipids were labelled by 3H-arachidonic acid (3H-AA) and 32P. Exaprolol, metipranolol and propranolol significantly modulated 32P incorporation into phospholipids of resting and 48/80 stimulated cells. Atenolol had no effect. Studies with 3H-AA Labelled mast cells showed an enhanced liberation of arachidonate related radioactivity on exaprolol and propranolol treatment. The results indicated that 3H-activity was lost mainly from phosphatidylethanolamine. Atenolol and metipranolol significantly decreased the 48/80 stimulated 3H-AA release.

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