Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Oct 15;11(20):4620-3.
doi: 10.1021/ol901892s.

Highly enantioselective alkylation reaction of enamides by Brønsted-acid catalysis

Qi-Xiang Guo  1 , Yun-Gui Peng, Jin-Wei Zhang, Liu Song, Zhang Feng, Liu-Zhu Gong
Affiliations

Highly enantioselective alkylation reaction of enamides by Brønsted-acid catalysis

Qi-Xiang Guo et al. Org Lett. .

Abstract

The H8-BINOL-derived, phosphoric acid catalyzed, highly enatioselective alkylation reaction of enamides with indolyl alcohols has been described. A phosphoric acid derived from H8-BINOL enabled an asymmetric alpha-alkylation of enamides with indolyl alcohols to give beta-aryl 3-(3-indolyl)propanones in high yields (up to 96%) and with excellent enantioselectivity (up to 96% ee).

PubMed Disclaimer

LinkOut - more resources