Review
doi: 10.1016/0167-5699(90)90100-n.
Defective signal transduction--a common pathway for cellular dysfunction in HIV infection?
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- PMID: 1974764
- DOI: 10.1016/0167-5699(90)90100-n
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Review
Defective signal transduction--a common pathway for cellular dysfunction in HIV infection?
Immunol Today.
1990 Jul.
Abstract
Qualitative defects in immune responsiveness after human immunodeficiency virus (HIV) infection have been well characterized and may play a key role in the development of HIV disease. However, no clear picture of the underlying mechanism of the functional deficiencies has yet emerged. In this article, Anthony Pinching and Keith Nye suggest that HIV or HIV proteins can sabotage transmembrane signalling and that this is of primary importance to the alterations in immune responsiveness.
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