Amino acid signaling to TOR activation: Vam6 functioning as a Gtr1 GEF
- PMID: 19748348
- DOI: 10.1016/j.molcel.2009.08.010
Amino acid signaling to TOR activation: Vam6 functioning as a Gtr1 GEF
Abstract
In this issue of Molecular Cell, Binda et al. identify Vam6/Vps39 as a guanine nucleotide exchange factor for Gtr1, a Rag family GTPase, to promote TORC1 activation in response to amino acids.
Comment on
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The Vam6 GEF controls TORC1 by activating the EGO complex.Mol Cell. 2009 Sep 11;35(5):563-73. doi: 10.1016/j.molcel.2009.06.033. Mol Cell. 2009. PMID: 19748353
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