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Comment
. 2009 Sep 12;374(9693):875-6; author reply 876-7.
doi: 10.1016/S0140-6736(09)61618-4.

The SERPING1 gene and age-related macular degeneration

Rando Allikmets, Michael Dean, Gregory S Hageman, Paul N Baird, Caroline C Klaver, Arthur A Bergen, Bernhard H Weber; International AMD Genetics Consortium
Collaborators
Comment

The SERPING1 gene and age-related macular degeneration

Rando Allikmets et al. Lancet. .
No abstract available

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Figures

Figure
Figure. Forest plot of the combined analysis of ten case–control cohorts from the three studies
Horizontal lines represent 95% CIs, and various-sized squares correspond to significance levels of p values. Test for heterogeneity was highly significant (p=3·1×10−15), suggesting that calculation of a combined odds ratio is not valid.
See this image and copyright information in PMC

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References

    1. Ennis S, Jomary C, Mullins R, et al. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. Lancet. 2008;372:1828–34. - PMC - PubMed
    1. Park KH, Ryu E, Tosakulwong N, Wu Y, Edwards AO. Common variation in the SERPING1 gene is not associated with age-related macular degeneration in two independent groups of subjects. Mol Vis. 2009;15:200–07. - PMC - PubMed
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    1. Hageman GS, Anderson DH, Johnson LV, et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA. 2005;102:7227–32. - PMC - PubMed

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