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. 2009 Oct 15;19(20):5919-23.
doi: 10.1016/j.bmcl.2009.08.059. Epub 2009 Aug 20.

Thienopyrimidine-based P2Y12 platelet aggregation inhibitors

Steven W Kortum  1 , Rhonda M Lachance, Barbara A Schweitzer, Gopichand Yalamanchili, Hayat Rahman, Michael D Ennis, Rita M Huff, Ruth E TenBrink
Affiliations

Thienopyrimidine-based P2Y12 platelet aggregation inhibitors

Steven W Kortum et al. Bioorg Med Chem Lett. .

Abstract

Herein we describe the design and synthesis of a novel series of potent thienopyrimidine P2Y12 inhibitors and the negative impact protein binding has on the inhibition of platelet aggregation.

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