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. 1990 Aug;7(4):566-72.
doi: 10.1016/0888-7543(90)90200-e.

Genetic mapping in the region of the mouse X-inactivation center

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Genetic mapping in the region of the mouse X-inactivation center

J T Keer et al. Genomics. 1990 Aug.

Abstract

The mouse X-inactivation center lies just distal to the T16H breakpoint. Utilizing pedigree analysis of backcross progeny from a Mus domesticus/Mus spretus interspecific cross, we have mapped a number of genetic loci, gene probes, microclones, and EagI linking clones distal to the T16H breakpoint. The genetic analysis provides a detailed genetic map in the vicinity of the mouse X-inactivation center. Comparative mapping data from the human X chromosome indicate that the most probable location of the mouse X-inactivation center is distal to Ccg-1 and in the region of the Pgk-1 locus. We report the assignment of two new loci, EM13 and DXSmh44, to the Ccg-1/Pgk-1 interval.

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