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Review
. 2009 Jun;67(6):206-11.

Should antiretroviral therapy for HIV infection be tailored for intracerebral penetration?

P P Koopmans  1 , R Ellis, B M Best, S Letendre
Affiliations
Review

Should antiretroviral therapy for HIV infection be tailored for intracerebral penetration?

P P Koopmans et al. Neth J Med. 2009 Jun.

Abstract

The continuous replication of HIV-1 in the central nervous system, in particular the brain, and its potential long-term deleterious effect is the focus of this review. Cognitive deficits are observed in a significant percentage of HIV-1-infected patients. That may occur despite successful peripheral suppression of the HIV-1 replication. Compartmentalisation of HIV-1 in the brain, genetic mutation of HIV-1, age, HCV coinfection and poor intracerebral penetration, as well as possibly a direct toxic effect of antiretroviral drugs, are factors that may account for potential creeping damage of the brain after many years of treatment. Patients with neurological symptoms or cognitive deficits may require another approach to the treatment of their HIV infection.

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Figures

Figure 1
Figure 1. Plasma and CSF HIV RNA concentrations in 31 HIV-1 seropositive patients
Plasma and CSF samples were taken at the same day with a maximal time span of one hour. Source: Radboud University Medical Center, Department of General Internal Medicine, Nijmegen, the Netherlands.
See this image and copyright information in PMC

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