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Comparative Study
. 2009 Sep 14:8:50.
doi: 10.1186/1475-2840-8-50.

MMP-1 serum levels predict coronary atherosclerosis in humans

Michael Lehrke  1 , Martin Greif, Uli C Broedl, Corinna Lebherz, Rüdiger P Laubender, Alexander Becker, Franz von Ziegler, Janine Tittus, Maximilian Reiser, Christoph Becker, Burkhard Göke, Gerhard Steinbeck, Alexander W Leber, Klaus G Parhofer
Affiliations
Comparative Study

MMP-1 serum levels predict coronary atherosclerosis in humans

Michael Lehrke et al. Cardiovasc Diabetol. .

Abstract

Background: Myocardial infarction results as a consequence of atherosclerotic plaque rupture, with plaque stability largely depending on the lesion forming extracellular matrix components. Lipid enriched non-calcified lesions are considered more instable and rupture prone than calcified lesions. Matrix metalloproteinases (MMPs) are extracellular matrix degrading enzymes with plaque destabilisating characteristics which have been implicated in atherogenesis. We therefore hypothesised MMP-1 and MMP-9 serum levels to be associated with non-calcified lesions as determined by CT-angiography in patients with coronary artery disease.

Methods: 260 patients with typical or atypical chest pain underwent dual-source multi-slice CT-angiography (0.6-mm collimation, 330-ms gantry rotation time) to exclude coronary artery stenosis. Atherosclerotic plaques were classified as calcified, mixed or non-calcified.

Results: In multivariable regession analysis, MMP-1 serum levels were associated with total plaque burden (OR: 1.37 (CI: 1.02-1.85); p < 0.05) in a model adjusted for age, sex, BMI, classical cardiovascular risk factors, hsCRP, adiponectin, pericardial fat volume and medication. Specification of plaque morphology revealed significant association of MMP-1 serum levels with non-calcified plaques (OR: 1.16 (CI: 1.0-1.34); p = 0.05) and calcified plaques (OR: 1.22 (CI: 1,03-1.45); p < 0.05) while association with mixed plaques was lost in the fully adjusted model. No associations were found between MMP9 serum levels and total plaque burden or plaque morphology.

Conclusion: MMP-1 serum levels are associated with total plaque burden but do not allow a specification of plaque morphology.

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Figures

Figure 1
Figure 1
Representative images of calcified (a), mixed (b) and non-calcified plaques (c) as detected by CT-angiography.
Figure 2
Figure 2
Correlation between MMP-1 serum levels and total plaque burden.
See this image and copyright information in PMC

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