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. 2009 Aug;5(4):311-7.
doi: 10.2147/tcrm.s4571. Epub 2009 May 4.

Antimalarials and the fight against malaria in Brazil

Luiz Ma Carmargo  1 , Saulo de Oliveira, Sergio Basano, Célia Rs Garcia
Affiliations

Antimalarials and the fight against malaria in Brazil

Luiz Ma Carmargo et al. Ther Clin Risk Manag. 2009 Aug.

Abstract

Malaria, known as the "fevers," has been treated for over three thousand years in China with extracts of plants of the genus Artemisia (including Artemisia annua, A. opiacea, and A. lancea) from which the active compound is artemisin, a sesquiterpene that is highly effective in the treatment of the disease, especially against young forms of the parasite. South American Indians in the seventeenth century already used an extract of the bark of chinchona tree, commonly named "Jesuits' powder." Its active compound was isolated in 1820 and its use spread all over the world being used as a prophylactic drug during the construction of the Madeira-Mamoré railroad in the beginning of the twentieth century. During the 1920s to the 1940s, new antimalarial drugs were synthesized to increase the arsenal against this parasite. However, the parasite has presented systematic resistence to conventional antimalarial drugs, driving researchers to find new strategies to treat the disease. In the present review we discuss how Brazil treats Plasmodium-infected patients.

Keywords: Plasmodium falciparum; antimalarials; calcium; malaria.

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References

    1. Hsu E. The history of qing hao in the Chinese materia medica. Trans R Soc Trop Med Hyg. 2006;100(6):505–508. - PubMed
    1. Goldring JD, Padayachee T, Ismail I. Plasmodium falciparum malaria: rosettes are disrupted by quinine, artemisinin, mefloquine, primaquine, pyrimethamine, chloroquine and proguanil. Mem Inst Oswaldo Cruz. 1999;94(5):667–674. - PubMed
    1. Camargo EP. Rev. Inst. Estudos avançados USP, São-Paulo-Brasil. 2005;9(24):211–227.
    1. Malária. Superintendência de Controle de Endemias. c2000–2001[cited 2008 Jun 18]. Available from: http://www.sucen.sp.gov.br/doencas/malaria/texto_malaria.htm.
    1. Bruce-Chwatt LJ. History of malaria from pre-history into erradication. In: Wernsdorfer WH, McGregor I, editors. Malaria: principles and practice of malariology. Edinburgh, UK: Churchill-Livingstone; 1988.