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. 2009 Oct;72(10):1899-901.
doi: 10.1021/np9004213.

Cassiarins C-E, antiplasmodial alkaloids from the flowers of Cassia siamea

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Cassiarins C-E, antiplasmodial alkaloids from the flowers of Cassia siamea

Shiori Oshimi et al. J Nat Prod. 2009 Oct.

Abstract

Three new alkaloids, cassiarins C-E (1-3), and a new chromone, 10,11-dihydroanhydrobarakol (4), which showed moderate antiplasmodial activity against Plasmodium falciparum 3D7, were isolated from flowers of Cassia siamea, and the structures of 1-4 were elucidated by 2D NMR analysis and chemical transformation. Cassiarin D (2) was a dimeric compound consisting of 5-acetonyl-7-hydroxy-2-methylchromone and cassiarin C (1), and cassiarin E (3) was a dimer of cassiarins A and C (1).

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