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. 1990 Sep 22;336(8717):712-4.
doi: 10.1016/0140-6736(90)92206-w.

Preliminary report: effects of interleukin-1 on platelet counts

A Tewari  1 , W C Buhles Jr, H F Starnes Jr
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Free article

Preliminary report: effects of interleukin-1 on platelet counts

A Tewari et al. Lancet. .
Free article

Retraction in

Abstract

Recombinant human interleukin-1 beta was given in 5 daily intravenous infusions to ten patients with metastatic malignant disorders as part of an antineoplastic trial. All ten patients experienced transient increases in heart rate, low-grade fevers, and rigors. A neutrophil-dominated 100% rise in leucocyte counts occurred 4-8 h after treatment. Leucocyte counts returned to baseline levels within 24 h of interleukin-1 beta infusion. A 50% rise in platelets occurred in response to interleukin-1 beta; the increase in platelet counts was first noted 6 days after treatment began and was sustained for 24 days after treatment. Interleukin-1 beta may therefore be beneficial in the treatment of conditions of thrombocytopenia associated with haematological disorders and chemotherapy for malignant disorders.

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Comment in

  • Haematological effects of interleukin-1.
    Dasgupta B. Dasgupta B. Lancet. 1990 Dec 15;336(8729):1506. doi: 10.1016/0140-6736(90)93210-g. Lancet. 1990. PMID: 1979111 No abstract available.
  • Final findings of scientific misconduct.
    [No authors listed] [No authors listed] NIH Guide Grants Contracts (Bethesda). 1994 Aug 12;23(30):2. NIH Guide Grants Contracts (Bethesda). 1994. PMID: 8031608 Free PMC article. No abstract available.

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