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. 2009 Sep 17;361(12):1216-8.
doi: 10.1056/NEJMc0902556.

A classic twin study of external ear malformations, including microtia

Maria A Artunduaga, Maria D L Quintanilla-Dieck, Steven Greenway, Rebecca Betensky, Yamileth Nicolau, Usama Hamdan, Patricia Jarrin, Gabriel Osorno, Burt Brent, Roland Eavey, Christine Seidman, J G Seidman

A classic twin study of external ear malformations, including microtia

Maria A Artunduaga et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Normal and Malformed Ears in One Pair of Monozygotic Twins
In Twin 1, the right ear shows severe microtia and aural atresia (Panel A), whereas the left ear is unaffected (Panel B). In Twin 2 the right ear is unaffected (Panel C), whereas the left ear (Panel D) shows mild microtia, consisting of a stenotic external ear canal (arrow) and a constricted helix.
See this image and copyright information in PMC

References

    1. Alasti F, Van Camp G. Genetics of microtia and associated syndromes. J Med Genet. 2009;46:361–9. - PubMed
    1. Neal GS, Hankins GD. Left microtia in one monozygotic twin: a case report. J Reprod Med. 1992;37:375–7. - PubMed
    1. Hussain M, Ball EA, Moss AL. Ipsilateral microtia in monozygotic twins: an unusual concordant phenotype. Plast Reconstr Surg. 2004;113:1293–4. - PubMed
    1. Wieczorek D, Ludwig M, Boehringer S, Jongbloet PH, Gillessen-Kaesbach G, Horsthemke B. Reproduction abnormalities and twin pregnancies in parents of sporadic patients with oculoauriculo-vertebral spectrum/Goldenhar syndrome. Hum Genet. 2007;121:369–76. - PubMed
    1. Digilio MC, Calzolari F, Capolino R, et al. Congenital heart defects in patients with oculo-auriculo-vertebral spectrum (Goldenhar syndrome) Am J Med Genet A. 2008;146A:1815–9. - PubMed

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