Review
doi: 10.1007/BF00404086.
Identification of susceptibility loci for type 1 (insulin-dependent) diabetes by trans-racial gene mapping
Affiliations
- PMID: 1976101
- DOI: 10.1007/BF00404086
Item in Clipboard
Review
Identification of susceptibility loci for type 1 (insulin-dependent) diabetes by trans-racial gene mapping
Diabetologia.
1990 Jul.
Abstract
A major component of inherited susceptibility to Type 1 (insulin-dependent) diabetes mellitus has been mapped to the major histocompatibility complex. Certain gene alleles in this region determine susceptibility and resistance to the disease. Mapping of susceptibility is hindered by the limitations of conventional tissue typing techniques, and by strong linkage disequilibrium within this part of the genome. Recombinant DNA technology and trans-racial studies have been used to allow finer mapping of genetic predisposition to Type 1 diabetes. These techniques have localised alleles encoding susceptibility and resistance to the DQ region. Other alleles determining disease susceptibility remain poorly localised.
Similar articles
-
Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping.Nature. 1989 Apr 13;338(6216):587-9. doi: 10.1038/338587a0. Nature. 1989. PMID: 2494458
-
Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to type 1 (insulin-dependent) diabetes mellitus.Diabetologia. 1993 May;36(5):371-7. doi: 10.1007/BF00402270. Diabetologia. 1993. PMID: 8314439 Review.
-
Allele-specific gene probing supports the DQ molecule as a determinant of inherited susceptibility to type 1 (insulin-dependent) diabetes mellitus.Diabetologia. 1991 Feb;34(2):109-13. doi: 10.1007/BF00500381. Diabetologia. 1991. PMID: 2065845
-
Genetic control of autoimmunity in type 1 diabetes.Immunol Today. 1990 Apr;11(4):122-9. doi: 10.1016/0167-5699(90)90049-f. Immunol Today. 1990. PMID: 2187469 Review.
-
Oligonucleotide probes for HLA-DQA and DQB genes define susceptibility to type 1 (insulin-dependent) diabetes mellitus.Diabetologia. 1988 Oct;31(10):751-7. doi: 10.1007/BF00274778. Diabetologia. 1988. PMID: 3240836
Cited by
-
HLA-DQ primarily confers protection and HLA-DR susceptibility in type I (insulin-dependent) diabetes studied in population-based affected families and controls.Am J Hum Genet. 1993 Jul;53(1):150-67. Am J Hum Genet. 1993. PMID: 8317480 Free PMC article.
-
Association between HLA and islet cell antibodies in diabetic patients with a mitochondrial DNA mutation at base pair 3243.Diabetologia. 1996 Oct;39(10):1196-200. doi: 10.1007/BF02658506. Diabetologia. 1996. PMID: 8897007
-
Tumour necrosis factor-beta polymorphism is unlikely to determine susceptibility to type 1 (insulin-dependent) diabetes mellitus.Diabetologia. 1991 Aug;34(8):576-8. doi: 10.1007/BF00400276. Diabetologia. 1991. PMID: 1682200
-
IDDM susceptibility associated with polymorphisms in the insulin gene region. A study of blacks, Caucasians and orientals.Diabetologia. 1994 Aug;37(8):745-9. doi: 10.1007/BF00404330. Diabetologia. 1994. PMID: 7988775 Clinical Trial.
-
Investigation of the mode of inheritance of insulin-dependent diabetes mellitus in Japanese subjects.Am J Hum Genet. 1992 May;50(5):1018-21. Am J Hum Genet. 1992. PMID: 1349195 Free PMC article.
References
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Medical