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. 2010 Nov;14(4):617-20.
doi: 10.1007/s11030-009-9193-1. Epub 2009 Sep 11.

A synthesis of phosphorylated dioxohexahydropyrimidines from N,N'-dimethylurea, activated acetylenes, and trialkyl phosphites

Issa Yavari  1 , Manijeh Nematpour, Zinatossadat Hossaini
Affiliations

A synthesis of phosphorylated dioxohexahydropyrimidines from N,N'-dimethylurea, activated acetylenes, and trialkyl phosphites

Issa Yavari et al. Mol Divers. 2010 Nov.

Abstract

An efficient synthesis of alkyl 5-(dialkoxy- phosphoryl)-1,3-dimethyl-2, 6-dioxo-hexahydropyrimidine-4-carboxylates is described. This involves the reaction of N,N'-dimethylurea and dialkyl acetylendicarboxylates in the presence of trialkyl phosphites. Under similar conditions, triphenyl phosphite led to alkyl 5-(diphenoxyphosphoryl)-1,3-dimethyl-2,6-dioxo-hexahydro-4-pyrimidinecarboxylates.

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