Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1990 Nov;9(11):3631-9.
doi: 10.1002/j.1460-2075.1990.tb07574.x.

Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity

S Guazzi  1 , M Price, M De Felice, G Damante, M G Mattei, R Di Lauro
Affiliations
Comparative Study

Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity

S Guazzi et al. EMBO J. 1990 Nov.

Abstract

The cDNA for TTF-1, a thyroid nuclear factor that binds to the promoter of thyroid specific genes, has been cloned. The protein encoded by the cDNA shows binding properties indistinguishable from those of TTF-1 present in nuclear extracts of differentiated rat thyroid cells. The DNA binding domain of TTF-1 is a novel mammalian homeodomain that shows considerable sequence homology to the Drosophila NK-2 homeodomain. TTF-1 mRNA and corresponding binding activity are detected in thyroid and lung. The chromosomal localization of the TTF-1 gene has been determined in humans and mice and corresponds to chromosomes 14 and 12, respectively, demonstrating that the TTF-1 gene is not located within previously described clusters of homeobox-containing genes.

PubMed Disclaimer

References

    1. Genomics. 1989 Oct;5(3):541-5 - PubMed
    1. EMBO J. 1989 Sep;8(9):2537-42 - PubMed
    1. Nature. 1990 Apr 26;344(6269):879-82 - PubMed
    1. EMBO J. 1986 Apr;5(4):733-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Jun;77(6):3455-9 - PubMed

Publication types

MeSH terms

Associated data